2021 Mercedes-Benz S-Class
US · Subcompact Cars
The 2021 Mercedes-Benz S-Class is listed in the US market. Every figure below carries the source it came from, and anything our sources do not publish is left out rather than estimated.
- Engine
- Varies by configuration: 4.0L 8-cylinder turbocharged (SIDI), 3.0L 6-cylinder (SIDI; Mild Hybrid), 4.0L 8-cylinder turbocharged (SIDI; Mild Hybrid)
- Transmission
- 9-speed automatic
- Drivetrain
- Varies by configuration: 4WD, RWD
- Fuel
- Varies by configuration: Gasoline, Hybrid
- Economy
- 17 mpg (13.8 L/100 km) to 24 mpg (9.8 L/100 km) combined
Key Figures
Engine
| Specification | Value | Source |
|---|---|---|
| Engine | Varies by configuration: 4.0L 8-cylinder turbocharged (SIDI), 3.0L 6-cylinder (SIDI; Mild Hybrid), 4.0L 8-cylinder turbocharged (SIDI; Mild Hybrid) | |
| Displacement | 3.0 L to 4.0 L | |
| Cylinders | 6 to 8 | |
| Aspiration | Turbocharged | |
| Fuel type | Varies by configuration: Gasoline, Hybrid | EPA fueleconomy.gov |
Transmission and drivetrain
| Specification | Value | Source |
|---|---|---|
| Transmission | Automatic | EPA fueleconomy.gov |
| Gears | 9 | |
| Drivetrain | Varies by configuration: 4WD, RWD |
Fuel economy and range
| Specification | Value | Source |
|---|---|---|
| Combined | 17 mpg (13.8 L/100 km) to 24 mpg (9.8 L/100 km) | EPA fueleconomy.gov |
| City | 14 mpg (16.8 L/100 km) to 20 mpg (11.8 L/100 km) | |
| Highway | 24 mpg (9.8 L/100 km) to 29 mpg (8.1 L/100 km) |
Our sources do not publish these for this vehicle: Power, Torque, Electric range, Battery capacity. We leave them out instead of estimating.
Trims and configurations
7 configurations listed by our sources. Engines, drivetrains and fuel economy can differ between them.
- AMG S63 4matic Plus Convertible · 4.0L · 4WD · 9-speed automatic
- AMG S63 4matic Plus Coupe · 4.0L · 4WD · 9-speed automatic
- S500 4matic · 3.0L · 4WD · 9-speed automatic · Hybrid
- S560 4matic Coupe · 4.0L · 4WD · 9-speed automatic
- S560 Convertible · 4.0L · RWD · 9-speed automatic
- S580 4matic · 4.0L · 4WD · 9-speed automatic · Hybrid
- S580 4matic Maybach · 4.0L · 4WD · 9-speed automatic · Hybrid
Recalls
No recall campaigns were found in NHTSA data at the last check. Last checked November 8, 2026.
Data sources
- EPA fueleconomy.gov · retrieved November 4, 2026 · US Government public data
- NHTSA vPIC · retrieved October 12, 2026 · US Government public data
Source checked: November 4, 2026
Data verified: November 4, 2026
Specifications can vary by market, trim, configuration and production date. Confirm with the manufacturer before buying parts or making safety decisions. Report an error.
Related vehicles
- 2020 Mercedes-Benz S-Class
Varies by configuration: Gasoline, Plug-in hybrid
Varies by configuration: 3.0L 6-cylinder turbocharged (SIDI), 4.0L 8-cylinder turbocharged (SIDI), 6.0L 12-cylinder turbocharged, 3.0L 6-cylinder turbocharged (SIDI; PHEV) · Varies by configuration: RWD, 4WD
22 mpg (10.7 L/100 km) to 16 mpg (14.7 L/100 km) - 2022 Mercedes-Benz S-Class
Varies by configuration: Hybrid, Gasoline
Varies by configuration: 3.0L 6-cylinder (SIDI; Mild Hybrid), 4.0L 8-cylinder turbocharged (SIDI; Mild Hybrid), 6.0L 12-cylinder turbocharged · AWD
24 mpg (9.8 L/100 km) to 15 mpg (15.7 L/100 km)
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Frequently asked questions
What engine does the 2021 Mercedes-Benz S-Class have?
Varies by configuration: 4.0L 8-cylinder turbocharged (SIDI), 3.0L 6-cylinder (SIDI; Mild Hybrid), 4.0L 8-cylinder turbocharged (SIDI; Mild Hybrid). Engines can differ by trim, so check the trim list below.
What is the fuel economy of the 2021 Mercedes-Benz S-Class?
Combined fuel economy is 17 mpg (13.8 L/100 km) to 24 mpg (9.8 L/100 km), as published by the source shown in the specification table.
Is the 2021 Mercedes-Benz S-Class front-wheel, rear-wheel or all-wheel drive?
Drivetrain: Varies by configuration: 4WD, RWD.
Are there recalls for the 2021 Mercedes-Benz S-Class?
No recall campaigns were found in NHTSA data when we last checked on November 8, 2026. Recall status can change, so confirm with NHTSA or the manufacturer.